E6383
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E6383
Sigma-Aldrich
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
crystalline
| Synonym: | EDAC, EDC hydrochloride, WSC hydrochloride, N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride |
| CAS Number: | 25952-53-8 |
| Linear Formula: | C8H17N3 · HCl |
| Molecular Weight: | 191.70 |
| Beilstein Registry Number: | 5764110 |
| EC Number: | 247-361-2 |
| MDL number: | MFCD00012503 |
| PubChem Substance ID: | 24894627 |
Description
| Biochem/physiol Actions | Water soluble condensing reagent. It is generally utilized as a carboxyl activating agent for amide bonding with primary amines. In addition, it will react with phosphate groups. It has been used in peptide synthesis; crosslinking proteins to nucleic acids; and preparation of immunoconjugates as examples. Typically, it is utilized in the pH range 4.0-6.0 without buffers. In particular, amine and carboxylate buffers should be avoided. |
Properties
| form | crystalline |
| mp | 110-115 °C(lit.) |
| solubility | H2O: ≤100 mg/mL |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| RTECS | FF2200000 |
References
| reference | Sheehan, J.C., and Ledis, Total synthesis of a monocyclic peptide lactone antibiotic, etamycin. J. Am. Chem. Soc. 95, 875-879, (1973) |
| Thomas, J.O., et al., Altered arrangement of the DNA in injection-defective lambda bacteriophage. J. Mol. Biol. 123, 149, (1978) | |
| Lundblad, R.L., et al., Modification of carboxyl groups in proteins, review. Chemical Reagents for Protein Modification, (1984) 2, 105 | |
| Drabick, J.J., et al., Covalent polymyxin B conjugate with human immunoglobulin G as an antiendotoxin reagent. Antimicrob. Agents Chemother. 42, 583-588, (1998) | |
| Dhaon, M.K., Synthesis of esters. J. Org. Chem. 47, 1962, (1982) |
